Systems Biology & High Performance Computing

Jeffrey Skolnick, Professor and Director of the Center for the Study of Systems Biology discusses high performance computing as related to his research at Georgia Tech

Building MYRIAD, the new CSSB Supercomputer

Penguin Computing talks about building "MYRIAD" - a 10,000+ CPU core, 100 teraflop top 100 ranked supercomputer for CSSB.

However, much like being given a parts list of a car without an instruction manual, the sequence of the human genome provides a list of about 25,000 proteins (the molecular machines of life), the functions of more than half of which are unknown. Moreover, analyzing the individual parts tells one very little about their synergistic interactions. Systems Biology seeks to understand how the components of complex living systems interact and give rise to life and how their malfunction causes disease.

medium_drug-resistance-protein_0.jpgDrug Design Strategy Boosts the Odds Against Resistance Development
A new rational drug design technique that uses a powerful computer algorithm to identify molecules that target different receptor sites on key cellular proteins could provide a new weapon in the battle against antibiotic resistance, potentially tipping the odds against the bugs.
Featured on: ScienceDaily, SciCentral, Medical Web Times and The EDGE


DNA Internal Motion Likely Accelerates Protein Target Search in a Packed Nucleoid dictates to a great extent the protein motion. See the article by Chow and Skolnick in the June 6 issue of Biophysical Journal. Related Article (news.gatech.edu): Rattling DNA Hustles Transcribers to Targets

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