Andrew P. McMahon, Harvard University, "Mechanisms of morphogen-mediated neural diversity in the mammalian central nervous system"

May 11 2010, 11:00 am
Distinguished Lecture Series Guest Speaker: 

Andrew P. McMahon

Department of Molecular and Cellular Biology, Harvard University

Date & Time: 
Wednesday May 11, 2010, 11:00AM
Location: 
Klaus 1116E
Host: 
J. Todd Streelman
Abstract: 
Generation of functional neural circuits is preceded by the localized induction of appropriate numbers of distinct neurons at specific positions within the developing nervous system. In vertebrates, concentration-dependent Sonic signaling from ventral mid-line tissues is responsible for position specific specification of distinct classes of neural progenitors. This model system provides one of the best described and most experimentally tractable examples of morphogen-based signaling processes. I will discuss our ongoing studies exploring the regulatory principles underpinning Sonic hedgehog patterning within the mammalian central nervous system.
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