Andrew P. McMahon, Harvard University, "Mechanisms of morphogen-mediated neural diversity in the mammalian central nervous system"

May 11 2010, 11:00 am
Distinguished Lecture Series Guest Speaker: 

Andrew P. McMahon

Department of Molecular and Cellular Biology, Harvard University

Date & Time: 
Wednesday May 11, 2010, 11:00AM
Klaus 1116E
J. Todd Streelman
Generation of functional neural circuits is preceded by the localized induction of appropriate numbers of distinct neurons at specific positions within the developing nervous system. In vertebrates, concentration-dependent Sonic signaling from ventral mid-line tissues is responsible for position specific specification of distinct classes of neural progenitors. This model system provides one of the best described and most experimentally tractable examples of morphogen-based signaling processes. I will discuss our ongoing studies exploring the regulatory principles underpinning Sonic hedgehog patterning within the mammalian central nervous system.
Additional Info: