Andrew P. McMahon, Harvard University, "Mechanisms of morphogen-mediated neural diversity in the mammalian central nervous system"
May 11 2010, 11:00 am
Distinguished Lecture Series Guest Speaker:
Andrew P. McMahon
Department of Molecular and Cellular Biology, Harvard University
Date & Time:Wednesday May 11, 2010, 11:00AM
Host:J. Todd Streelman
Generation of functional neural circuits is preceded by the localized induction of appropriate numbers of distinct neurons at specific positions within the developing nervous system. In vertebrates, concentration-dependent Sonic signaling from ventral mid-line tissues is responsible for position specific specification of distinct classes of neural progenitors. This model system provides one of the best described and most experimentally tractable examples of morphogen-based signaling processes. I will discuss our ongoing studies exploring the regulatory principles underpinning Sonic hedgehog patterning within the mammalian central nervous system.