Bruce Berne, Columbia University, "Hydrophobicity on small and large length scales"

Oct 12 2010, 11:00 am
Distinguished Lecture Series Guest Speaker: 

Bruce Berne

Higgins Professor
Department of Chemistry
Columbia University

Date & Time: 
Tuesday, October 12, 2010, 11:00AM
Location: 
Klaus 1116E
Host: 
Jeffrey Skolnick
Abstract: 
Hydrophobicity manifests itself differently on large and small and length scales in physical and biomoleclar systems. We discuss the role of different length scale effects in protein folding and unfolding, the denaturing action of urea, and ligand binding to proteins.
Additional Info: 

Dr. Berne's lab's research focuses on understanding structural and dynamical processes in condensed matter and biophysical systems. Because they study many-body systems, it is necessary to utilize the powerful analytical methods of equilibrium and time-dependent quantum statistical mechanics as well as state-of-the art computer simulation methods such as molecular dynamics and quantum Monte-Carlo techniques. One important aspect of their research is the invention of new simulation. Recent work along these lines is their invention of a novel multiple time scale method in molecular dynamics and its application to the simulation of biomacromolecules, hydrophobicity, the detailed mechanism of chemical denaturation, and the effect of force on proteins. Another important activity involves the invention of new dynamical fluctuating charge force fields for complex molecular assemblies.

Faculty Website
Lab Website
Bruce Berne - Seminar Flier.jpg