Dietmar Schomburg, Technical University of Braunschweig: "Joining Bioinformatics and metabolome research to systems biology models"
Feb 12 2008, 11:00 am
Distinguished Lecture Series Guest Speaker:
Professor and Director, Department of Bioinformatics and Biochemistry
Technical University of Braunschweig
Date & Time:Tuesday February 12, 2008
Complex biological phenomena like complex diseases, pathogen/host interactions or microbial performance in fermentation processes are reactions of the whole biological system and can only be understood as such and predicted successfully by simulation of molecular networks in the cell. The most complex of these systems is the metabolic network. which represents the main focus of experimental and bioinformatics research and development at the Schomburg group. In the context of genotype/phenotype correlation by characterisation and simulation of molecular networks the talk will address the following points: Metabolomics Experimental facts and standards as requirement for systems biology approaches. The need for nomenclature and experimental standardisation for accessibility and comparability of experimental data. The bioinformatics analysis of molecular networks. Approaches for the simulation of metabolic networks. Fluxes and pools of metabolites. Constraint-based flux analysis. The current developments at BRENDA, the world's largest enzyme information system.