Dinshaw J. Patel, Sloan-Kettering Institute, "Structural Biology of Small RNA-mediated Gene Regulation and Methylation-mediated Epigenetic Regulation"
Dinshaw J. Patel
Abby Rockefeller Mauze Chair in Experimental Therapeutics
Structural Biology Program
Memorial Sloan-Kettering Cancer Institute
Dr. Patel's group applies crystallographic and solution NMR techniques to investigate macromolecular-mediated recognition, regulation and catalysis. The major thrust of the laboratory is currently in the structural biology of RNA silencing and the histone/epigenetics code. Significant efforts are also underway towards a molecular understanding of RNA-mediated events involving riboswitches and ribozymes, as well as protein-RNA recognition events impacting on disease syndromes. Other projects include higher order DNA architectures with an emphasis on DNA quadruplexes, and the replication of DNA damage sites by bypass polymerases. Finally, our group also studies the molecular basis of glycosphingolipid binding specificity.