Ernest Fraenkel, Massachusetts Institute of Technology: "Using High-Throughput Data to Understand Transcriptional Regulation"
Apr 1 2008, 11:00 am
Distinguished Lecture Series Guest Speaker:
Assistant Professor, Department of Biological Engineering
Massachusetts Institute of Technology
Date & Time:Tuesday April 01, 2008
Transcription regulation has a central role in development, disease and evolution. Recently, new technologies have made it possible to analyze simultaneously how a protein contributes to the regulation of the expression of each gene in the genome.Using these genome-wide measurements, we have explored how liver transcription is regulated in humans and mice. In this talk I will describe an apparent paradox: although gene expression is conserved between the livers of humans and mice, and the sequence of the regulatory proteins are also highly conserved, most of the sites to which these proteins bind differ between species. I will present recent unpublished data that may provide a solution to this paradox.