Gordon G. Hammes, Duke University ,"Understanding Enzymes: Protein Conformation Coupled Catalysis"
Mar 23 2010, 11:00 am
Distinguished Lecture Series Guest Speaker:
Gordon G. Hammes
University Distinguished Service Professor of Biochemistry, Emeritus, Duke University
Professor Emeritus, Chemistry and Chemical Biology, Cornell University
Date & Time:Tuesday March 23, 2010, 11:00AM
The role of conformational changes in enzyme catalysis will be discussed. A model will be advanced consisting of conformational ensembles and multiple reaction pathways to explain the incredible catalytic efficiency of enzymes. The results of ensemble and single-molecule experiments obtained with dihydrofolate reductase will be presented that support this model.
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