Nick Grishin, The University of Texas Southwestern Medical Center at Dallas: "Protein comparison: from new methods to unexpected discoveries"
Mar 11 2008, 11:00 am
Distinguished Lecture Series Guest Speaker:
Assistant Professor, Department of Biochemistry
The University of Texas Southwestern Medical Center at Dallas
Investigator, Howard Hughes Medical Institute
Date & Time:Tuesday March 11, 2008
Several new methods for remote homology inference between proteins, multiple alignment and structure similarity search will be discussed; and their applications to uncover unexpected and biologically meaningful connections between proteins will be demonstrated. In particular, a few examples of evolutionarily related proteins with very different spatial structure will be shown. The most extreme case is an all-beta barrel protein family with a few members folded as an alpha-helical hairpin.