Timothy H. Bestor, Columbia University, "Biology of Genomic Methylation Patterns"

Apr 22 2010, 11:00 am
Distinguished Lecture Series Guest Speaker: 

Timothy H. Bestor

Professor, Genetics and Development
Columbia University Medical Center

Date & Time: 
Thursday April 22, 2010, 11:00AM
Location: 
MoSE/MSE G011
Host: 
Yuhong Fan
Abstract: 
I'll talk about a new hypothesis that attributes a role for altered DNA methylation patterns in cancer in a defense against carcinogenesis; this model contradicts the prevailing model under which methylation abnormalities contribute to carcinogenesis. I will also present the first high-resolution and high coverage methylation profiles of both normal and cancerous genomes, and I will discuss the new structure of DNMT1 (from Jikui Song and Dinshaw J. Patel) which predicts a surprising new mechanisms for the selective methylation of hemimethylated sites during S phase. These mechanisms explain much of the faithful inheritance of genomic methylation patterns that occurs in mammals.
Additional Info: