Timothy H. Bestor, Columbia University, "Biology of Genomic Methylation Patterns"
Apr 22 2010, 11:00 am
Distinguished Lecture Series Guest Speaker:
Timothy H. Bestor
Professor, Genetics and Development
Columbia University Medical Center
Date & Time:Thursday April 22, 2010, 11:00AM
I'll talk about a new hypothesis that attributes a role for altered DNA methylation patterns in cancer in a defense against carcinogenesis; this model contradicts the prevailing model under which methylation abnormalities contribute to carcinogenesis. I will also present the first high-resolution and high coverage methylation profiles of both normal and cancerous genomes, and I will discuss the new structure of DNMT1 (from Jikui Song and Dinshaw J. Patel) which predicts a surprising new mechanisms for the selective methylation of hemimethylated sites during S phase. These mechanisms explain much of the faithful inheritance of genomic methylation patterns that occurs in mammals.