Wayne Hendrickson, Columbia Univ. Medical Center, "Transduction of Biochemical Signals across Membrane into Cells"
Jan 19 2010, 11:08 am
Distinguished Lecture Series Guest Speaker:
Wayne A. Hendrickson
Professor, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center
Professor, Department of Pharmacy, Columbia University
Howard Hughes Medical Institute Investigator
Date & Time:Tuesday January 19, 2010
Biological cells need to be responsive to diverse environmental stimuli. For the most part, these stimuli are chemical compounds that do not readily permeate the cell membrane, and transmembrane receptor proteins must interact with these chemicals to make changes that can be detected inside the cell for the initiation of physiological responses. There is a great diversity of membrane receptors, and it appears that the biophysical mechanisms by which they transduce signals across the membrane barrier are also diverse. Within this diversity, however, many receptors do fall into just a few predominant receptor classes. These include tyrosine kinase receptors, histidine kinase receptors, G-protein coupled receptors and Cys-loop ligand gated ion channels. I will describe structural studies on such receptors that are aimed at developing insights into the principles and mechanisms of signal transduction across biological membranes.