William (Bill) A. Eaton, National Institute of Diabetes and Digestive and Kidney Diseases,"Single Molecule Photon Trajectories and Transition Path Times in Protein Folding
Feb 16 2010, 11:00 am
Distinguished Lecture Series Guest Speaker:
William (Bill) A. Eaton
Chief, Laboratory of Chemical Physics (LCP), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health
Date & Time:Tuesday February 16, 2010
The transition path time in kinetics is the tiny fraction of an equilibrium trajectory for a single molecule when the transition actually happens and has not been measured for any molecular process in solution. From measurements of photon-by-photon trajectories for donor-and-acceptor-fluorophore-labeled single protein molecules undergoing folding and unfolding transitions we have determined that the upper bound for the transition path time is more than 10,000-fold less than the mean first passage time, consistent with a Kramers™ analysis of diffusive barrier crossings.