Steered molecular dynamics and mechanical functions of proteins

TitleSteered molecular dynamics and mechanical functions of proteins
Publication TypeJournal Article
Year of Publication2001
AuthorsIsralewitz, B, Gao M, Schulten K
JournalCurrent opinion in structural biology
Date Published2001 Apr

Atomic force microscopy of single molecules, steered molecular dynamics and the theory of stochastic processes have established a new field that investigates mechanical functions of proteins, such as ligand-receptor binding/unbinding and elasticity of muscle proteins during stretching. The combination of these methods yields information on the energy landscape that controls mechanical function and on the force-bearing components of proteins, as well as on the underlying physical mechanisms.

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Alternate JournalCurr. Opin. Struct. Biol.