CANCELED: Arthur Skoultchi, Albert Einstein College of Medicine, "Controlling the Proliferation Versus Differentiation Decision in Normal and Malignant Blood Cells"

Jan 11 2011, 11:00 am
Distinguished Lecture Series Guest Speaker: 

Arthur Skoultchi

Professor, Chair and Judith and Burton P. Resnick Chair in Cell Biology
Department of Cell Biology
Albert Einstein College of Medicine of Yeshiva University

Date & Time: 
Tuesday, January 11, 2011, 11:00AM
Location: 
Klaus 1116E
Host: 
Yuhong Fan
Abstract: 
Our laboratory is investigating the mechanisms controlling mammalian development and cell differentiation by transcription factors and other proteins that affect the structure and function of chromatin. The subject of today’s seminar is the mechanisms used by red blood cells to control and coordinate their proliferation and differentiation programs. I will discuss our work showing that the proliferation versus differentiation decision in both normal red blood cell progenitors and malignant erythroleukemia cells is controlled by the relative amounts of two transcription factors, GATA-1, the master regulator of erythropoiesis, and PU.1 , the myeloid and B-cell specific factor that we have found also plays an important role in immature red blood cells. I will also discuss experiments showing that there is extensive cross talk between these two transcription factors and G1 cell cycle regulators and that this network is responsible for controlling and coordinating the cell’s proliferation and differentiation decisions.
Additional Info: 

Dr. Skoultchi's laboratory is interested in understanding the mechanisms controlling mammalian development and cell differentiation. Their approach is to investigate systems in which these processes are disturbed, either by malignant transformation (leukemia) or by directed gene inactivation in mice and Drosophila. Currently there are three major projects underway in his lab: Molecular Mechanisms of Leukemia, Role of H1 Linker Histones and Chromatin Remodeling Factors in Chromatin Structure, DNA Methylation, Gene Expression and Development in Mice and Drosophila, and Human ES Cell Proliferation and Totipotency.

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Arthur Skoultchi - Seminar Flier.jpg