Paul Clemons, Broad Institute, "Cheminformatic and assay-performance profiling of small-molecule screening collections"
Director, Computational Chemical Biology Research
Chemical Biology Program
Paul Clemons is Director, Computational Chemical Biology Research for The Broad Institute’s Chemical Biology Program. Clemons and his team use quantitative measurement, computational, and visualization techniques to enable systematic use of small molecules to explore biology, especially disease biology. In collaboration with biologists, Clemons’ team works to understand the consequences of small-molecule action on cells, particularly using multiple readouts, such as gene-expression profiles or profiles based on cellular imaging. With chemists, Clemons helps to identify the consequences of synthetic chemistry decisions on small-molecule performance, with the goal of developing optimal small-molecule screening collections. Current research activities in the Clemons group include quantification of chemical diversity of small-molecule collections, use of small molecules to profile biological processes in cellular contexts, and multidimensional analysis of large datasets resulting from small-molecule profiling.