Wesley I. Sundquist, The University of Utah, “The ESCRT pathway in HIV Budding and Cell Division”
Wesley I. Sundquist, Ph.D.
H.A. and Edna Benning Presidential Endowed Chair, Professor & Co-Chair
Department of Biochemistry
The University of Utah
We are interested in the molecular and structural biology of retroviruses, with particular emphasis on the Human Immunodeficiency Virus (HIV). Projects in the laboratory focus on understanding the architecture and assembly of the viral particle, the mechanisms of intrinsic host cell defenses, and the process of virus budding. Our approaches include NMR, EM, and crystallographic studies of viral complexes, biochemical analyses of the interactions between viral components and their cellular partners, and genetic analyses of viral protein functions.