ISN1 nucleotidases and HAD superfamily protein fold: in silico sequence and structure analysis.

TitleISN1 nucleotidases and HAD superfamily protein fold: in silico sequence and structure analysis.
Publication TypeJournal Article
Year of Publication2007
AuthorsSrinivasan, B, Balaram H
JournalIn silico biology
Volume7
Pagination187-93
Date Published2007
Abstract

cN-II class of 5' purine nucleotidases exhibit specificity for IMP/GMP and belong to the HAD (haloacid dehalogenase) superfamily of hydrolases. The recently identified ISNI class of IMP specific 5'-nucleotidases occurring in yeast, fungi and certain Plasmodia lack sequence homology with the cN-II class of enzymes. We show from analysis of motif and fold conservation that ISN1s also belong to the HAD superfamily. This identification adds a new novel member to this superfamily.

PDFhttp://cssb.biology.gatech.edu/skolnick/img/pdfs/insilicobiol1.pdf
Pub Med Link

http://www.ncbi.nlm.nih.gov/pubmed/17688444?dopt=Abstract

Alternate JournalIn Silico Biol. (Gedrukt)
Citekey17688444