Are predicted protein structures of any value for binding site prediction and virtual ligand screening?

TitleAre predicted protein structures of any value for binding site prediction and virtual ligand screening?
Publication TypeJournal Article
Year of Publication2013
AuthorsSkolnick, J, Zhou H, Gao M
JournalCurrent opinion in structural biology
Volume23
Pagination191-7
Date Published2013 Apr
Abstract

The recently developed field of ligand homology modeling (LHM) that extends the ideas of protein homology modeling to the prediction of ligand binding sites and for use in virtual ligand screening has emerged as a powerful new approach. Unlike traditional docking methodologies, LHM can be applied to low-to-moderate resolution predicted as well as experimental structures with little if any diminution in performance; thereby enabling ∼75% of an average proteome to have potentially significant virtual screening predictions. In large scale benchmarking, LHM is able to predict off-target ligand binding. Thus, despite the widespread belief to the contrary, low-to-moderate resolution predicted structures have considerable utility for biochemical function prediction.

PDFhttp://cssb.biology.gatech.edu/skolnick/publications/pdffiles/340.pdf
10.1016/j.sbi.2013.01.009
Pub Med Link

http://www.ncbi.nlm.nih.gov/pubmed/23415854?dopt=Abstract

Alternate JournalCurr. Opin. Struct. Biol.
Citekey340