OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.

TitleOleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.
Publication TypeJournal Article
Year of Publication2017
AuthorsHughes, RR, Shaaban KA, Zhang J, Cao H, Phillips GN, Thorson JS
JournalChembiochem : a European journal of chemical biology
Volume18
Pagination363-367
Date Published2017 Feb 16
Abstract

We describe the ability of an engineered glycosyltransferase (OleD Loki) to catalyze the N-glycosylation of tertiary-amine-containing drugs and trichostatin hydroxamate glycosyl ester formation. As such, this study highlights the first bacterial model catalyst for tertiary-amine N-glycosylation and further expands the substrate scope and synthetic potential of engineered OleDs. In addition, this work could open the door to the discovery of similar capabilities among other permissive bacterial glycosyltransferases.

10.1002/cbic.201600676
Pub Med Link

http://www.ncbi.nlm.nih.gov/pubmed/28067448?dopt=Abstract

Alternate JournalChembiochem
Citekey28067448