
Dr. Lee works in the area of large-scale combinatorial optimization, mathematical programming, algorithmic design, and parallel computation, with emphases on biological, medical, health systems, and logistics applications. Dr Lee has developed clinical decision-support systems to help analyze large-scale biological, DNA/genomic, and clinical data to assist in disease diagnosis and prediction, optimal treatment design and drug delivery, treatment and healthcare outcome analysis and prediction, and healthcare operations logistics. In logistics, Lee's research focuses on large-scale optimization for optimal operations planning and resource allocation. She has developed decision support systems for inventory control, large-scale vehicle dispatching, scheduling, transportation logistics, telecommunications, portfolio investment, and public health emergency treatment response and facility location and planning. Dr. Lee has received seven patents on innovative medical systems and devices; her research has been featured and discussed in New York Times, London Times, Urology Times, Atlanta Business Chronicle, and the Homeland Security IAIP Directorate Daily Report. Her cancer research was featured in a TV science news segment for "Discoveries and Breakthroughs Inside Science", broadcast by television stations nationwide. Current applications include large-scale bio/medical informatics, modeling, and computing for:
| EK Lee, K Gupta, T Easton, Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research, Optimization in Medicine 2006. To appear December 2006. |
| EK Lee, S Maheshwary, J Mason, W Glisson, Large-scale dispensing for emergency response to bioterrorism & infectious disease outbreak. Interfaces -- OR Applications for Homeland Defense 2006.To appear November 2006. |
| EK Lee, T Fox, I Crocker, Simultaneous beam geometry and intensity map optimization in intensity-modulated radiation therapy. International Journal of Radiation Oncology, Biology and Physics 64(1): 301-320, 2006. |
| FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, DNA Motifs Associated with aberrant CpG Island methylation, Genomics, 87: 572-579, 2006. |
| L Simpson, EK Lee, BJ Hott, DJ Vega and WM Book, Long-term results of angioplasty versus stenting in cardiac transplant recipients with allograft vasculopathy. The Journal of Heart and Lung Transplantation, 24(9): 1211-1217, 2005. |
| EK Lee, RJ Gallagher, A Campbell, M Prausnitz, Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra. IEEE Transactions on Biomedical Engineering, 51(1): 1-9, 2004. |
| FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, Predicting Aberrant CpG Island Methylation, Dec 2002. Proceedings of the National Academy of Science, 100(21):12253-12258, 2003. |