Georgia Institute of TechnologyCSSB
alt tag for imagealt tag for imagealt tag for image

Dr. Facundo Fernandez

Assistant Professor

School of Chemisty and Biochemisty

member
Dr. Facundo Fernandez

    Contact information:
  • School of Chemisty and Biochemisty
  • 770 State Street
  • Atlanta, GA 30332, Mail Code: 0400
  • Tel: 404-385-4432
  • Fax: 404-385-6447
  • Email:

Research Interests

In the last 20 years we have witnessed a revolution in Analytical Chemistry. This revolution has been caused by the need of rapid and accurate protein identification. Separation science and mass spectrometry are the two key fields where these changes are evident. Since the invention of the protein identification scheme known as 'peptide mass fingerprinting' in the late 80s'; a rapid succession of discoveries led to the creation of the broad field of proteomics. Proteomics is a technology driven field, and, as such, it relies on the development of instrumentation used for chemical analysis. Inspired by this revolution, in our laboratories we design, model and build new mass spectrometers based on orthogonal time-of-flight analyzers and monolithic ion-mobility drift cells. New microfabricated ion sources and ambient pressure ionization tools are also part of our research program. We believe that novel mass spectrometry-based instrumentation will ultimately lead to better diagnostics tools for disease, environmental monitoring and drug quality assessment. The multidimensional information generated by our instrumental platforms is mined using multivariate techniques to perform classification and quantitation in multidimensional space.

Faculty Page

Selected Publications

Articles Accepted / In Press

"Fast Screening and Chemical Fingerprinting of Counterfeit Antimalarial Tablets by Raman Spectroscopy" M. de Veij, P. Vandenabeele, K. Alter Hall, F.M. Fernandez, M. Green, N.J. White, A. Dondorp, P.N Newton and L. Moens. accepted, J. Raman Spectroscopy, 2006.
"Characterization of Solid Counterfeit Drug Samples by Desorption Electrospray Ionization and Direct-analysis-in-real-time Coupled to Time-of-flight Mass Spectrometry". Facundo M. Fernandez, Robert B. Cody, Michael D. Green, Christina Y. Hampton, Rose McGready, Sivong Sengaloundeth, Nicholas J. White, Paul N. Newton. accepted, ChemMedChem, 2006.
"Manslaughter by fake artesunate in Asia -will Africa become 'infected' next?", Paul N Newton, Rose McGready, Facundo Fernandez, Michael D Green, Souly Phanouvong, Christopher Whitty, Ambrose O. Talisuna, Stephane Proux, Eva Maria Christophel, Grace Malenga, Pratap Singhasivanon, Kalifa Bojang, Kevin Palmer, Nicholas PJ Day, Brian Greenwood, Francois Nosten, Nicholas J White. accepted, PLoS Medicine, 2006.
"Protein Identification via Surface-induced Dissociation in an FT-ICR Mass Spectrometer and a Patchwork Sequencing Approach", Facundo M. Fernandez, Vicki H. Wysocki, Jean H. Futrell and Julia Laskin. accepted, J. Am. Soc. Mass Spectrom., 2006.

Peer-Reviewed Articles

"Fast Hadamard Transform Capillary Electrophoresis for On-line, Time-Resolved Chemical Monitoring" Kevin L. Braun; Suminda Hapuarachi; Facundo M. Fernandez; Craig A. Aspinwall, Anal. Chem., 2006, 78, 1628-1635.
"A Link Between Lead and Cadmium Kinetic Speciation in Seawater and Accumulation by the Green Alga Ulva lactuca" J.O. Muse, C.N. Carducci, J.D. Stripeikis, M.B. Tudino, F.M. Fernandez. Env. Poll., 2006, 141, 126-130.
"Micromachined Ultrasonic Nanoelectrospray Microarray for High Throughput Mass Spectrometry", S. Aderogba, J. M. Meacham, F. M. Fernandez, F. L. Degertekin, and A. G. Fedorov. App. Phys. Lett., 2005, 86, 203110/1-203110/3.
"Submicrosecond Surface-Induced Dissociation of, Peptide Ions in a MALDI TOF MS". Chaminda M. Gamage, Facundo M. Fernandez, Krishnamoorty Kuppannan, Vicki, H. Wysocki. Anal. Chem., 2004, 76, 5080-5091.
"Continuous Two-Channel Time-of-flight Mass Spectrometric Detection of Electrosprayed Ions" Oliver Trapp, Joel R. Kimmel, Oh Kyu Yoon, Ignacio A. Zuleta, Facundo M. Fernandez, Richard, N. Zare. Angew. Chem. Int. Ed., 2004, 43, 6541-6544.
"Hadamard Transform Time-of-flight Mass Spectrometry: More Signal, More of the Time", Richard N. Zare, Facundo M. Fernandez, Joel R. Kimmel, Angew. Chem. Int. Edit., 2003, 42, 30-35.
"Effects of Modulation Defects on Hadamard Transform Time-of-flight Mass Spectrometry (HT-TOFMS)", Joel R. Kimmel, Facundo M. Fernandez, Richard N. Zare, J. Am. Soc. Mass Spectrom., 2003, 14, 278-286.
"Peptide Sequencing Using a Patchwork Approach and Surface-induced Dissociation in Sector-TOF and a Dual Quadrupole Mass Spectrometers" Facundo M. Fernandez, Lori L. Smith, Krishnamoorthy Kuppannan, Xi Yang, Vicki H. Wysocki. J. Am. Soc. Mass Spectrom., 2003, 14, 1387-1401.
"Synthesis of Novel Chelating Resins Containing Dithiophosphoric Functionality and Comparison to Analogous Solvent-Impregnated Resins (SIR's)" Abraham Warshawsky, Alexander G. Strikovsky, Facundo M. Fernandez, Karel Jerabek. Separ. Sci. Technol., 2002, 37(4), 1-24.
"Hadamard Transform Time-of-flight Mass Spectrometry: A High-speed Detector for Capillary Format Separations" Facundo M. Fernandez, Jose M. Vadillo, Joel R. Kimmel, Magnus Wetterhall, Karin Markides, Nestor Rodriguez, Richard N. Zare. Anal. Chem., 2002, 74, 1611-1617.
"Multicomponent Kinetic Determination of Cu, Zn, Co, Ni and Fe at Trace Levels by First and Second Order Multivariate Calibration" Fernandez, F. M.; Tudino, M. B.; Troccoli, O. E. Anal. Chim. Acta 2001, 433(1), 119-133.
"Effect of Sequence Length, Sequence Frequency, and Data Acquisition Rate on the Performance of a Hadamard Transform Time-of-Flight Mass Spectrometer" Facundo. M. Fernandez, Nestor Rodriguez, Jose M. Vadillo, Magnus Wetterhall, Karin Markides, Friedrich Engelke, Joel R. Kimmel, Richard N. Zare. J. Am. Soc. Mass Spectrom., 2001, 12(12), 1302-1311.
"Automatic On-line Ultratrace Determination of Cd Species of Environmental Significance by FI-ETA-AAS" Facundo M. Fernandez., Mabel B. Tudino, Osvaldo E. Troccoli. J. Anal. Atom. Spectrom. 2000, 15 (6), 687-695.
"Seaweeds in the Assessment of Heavy Metals Pollution in Gulf San Jorge, Argentina" J. Muse, J. Stripeikis, F. M. Fernandez, L. d'Huicque, M. Tudino, C. Carducci & O. Troccoli. Environ. Pollut., 1999, 104, 315-322.
"Novel Application and Comparison of Multivariate Calibration for the Simultaneous Determination of Cu, Zn, and Mn at Trace Levels using Flow Injection and Diode Array Spectrophotometry", Maia Azubel, Facundo M. Fernandez, Mabel Tudino & Osvaldo Troccoli. Anal. Chim. Acta, 1999, 398, 93-102.
"Fully Automatic On-Line Separation Preconcentration System for Electrothermal Atomic Absorption Spectrometry: Determination of Cadmium and Lead in Sea-water" Facundo M. Fernandez, Jorge D. Stripeikis, Mabel B. Tudino, Osvaldo E. Troccoli. Analyst 1997, 122, 679-684.
"Simultaneous Spectrophotometric Determination of Calcium and Magnesium in Mineral Waters by Means of Multivariate Partial Least-squares Regression." F. Blasco, M.J. Medina Hernandez, S. Sagrado, F. M. Fernandez. Analyst 1997, 122, 639-643.
"Improvements in the Flow Injection Determination of Nitrate and Nitrite in Natural Waters. Application to River Waters from Argentina" F. Fernandez, M. Tudino, O. Troccoli. Anal. Asoc. Quim. Arg. 1995, 83(3-4).

Peer-Reviewed Reviews

"Fake Artesunate in SE Asia", Paul N. Newton, Facundo M. Fernandez, Michael Green. accepted, Lancet Infectious Diseases, 2006.