
Dr. Lu's research at Tech lies at the interface of engineering and neuroscience. Her group uses engineering principles to develop modeling tools and fabrication tools to design and manufacture unique BioMEMS (Bio Micro-Electro-Mechanical System) devices to answer neuroscience questions that are difficult with conventional techniques. She is interested in how neurons behave and function, how genes and environment together determine diseased states, and how genetic, chemical, and physical interventions can possibly treat these diseases in both lower organisms and mammalian systems. Applied to the study of fundamental biological questions, these new techniques allow us to gather quantitative data about complex neuronal systems. Her group is interested in signal transduction networks of the neurons (e.g. gene expression levels), activities of the neurons in the network (e.g. neuronal firing patterns), and the resulting complex behaviors of the animals (e.g. locomotion). In the same way, Dr. Lu plans to use these techniques to aid the discovery of therapeutic molecules and the development of therapeutic strategies in neurodegenerative diseases.
| Yun Zhang, Hang Lu, Cornelia I. Bargmann, "Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans", Nature, 2005, 438 (7065): 179-184. |
| Jesse M. Gray*, David S. Karow*, Hang Lu, Andy J. Chang, Jennifer S. Chang, Ron Ellis, Michael A. Marletta, and Cornelia I. Bargmann, "Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue", Nature, 2004, 430 (6997): 317-322 |
| Hang Lu, Martin A. Schmidt, and Klavs F. Jensen, "Electroporation Microdevice for Controlled Cell Lysis", Lab on a Chip, 2005; 5 (1), 23-29 |
| Hang Lu, Klavs F. Jensen, "Intracellular Analysis On-Chip", Lab-on-a-chips for Cellomics: Micro and Nanotechnologies for Life Science, Ed. H. Andersson and A. van den Berg, invited. |
| Hang Lu*, Lily Y. Koo*, W. Maria Wang, Douglas A. Lauffenburger, Linda G. Griffith, Klavs F. Jensen, "Microfluidic Shear Devices for Quantitative Analysis of Cell Adhesion", Analytical Chemistry 2004; 76 (18), 5257-5264 |
| Hang Lu, Suzanne Gaudet, Martin A. Schmidt, and Klavs F. Jensen, "A Microfluidic Device for Subcellular Organelle Sorting", Analytical Chemistry 2004; 76 (19), 5705-5712 |
| Joerg Lahann, Mercedes Balcells, Hang Lu, Teresa Rodon, Klavs F. Jensen, and Robert Langer, "Reactive Polymer Coatings: A First Step Towards Surface Engineering of Microfluidic Devices", Analytical Chemistry 2003; 75 (9): 2117-2122 |
| Hang Lu, Martin A. Schmidt, and Klavs F. Jensen, "Photochemical Reactions and On-line UV Detection in Microfabricated Reactors", Lab on a Chip 2001; 1 (1): 22 |