Pamela Silver
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Professor, Department of Systems Biology |
Pamela Silver |
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Abstract: Biology presents us with an array of design principles based on both co-and post-transcriptional events. Synthetic Biology has emerged as a way to think about these processes in a logical manner to both understand cells by rebuilding them but also as a way to re-think cell-based bioengineering. We are interested in combining transcription-based logic with post-transcriptional logic such as protein localization and degradation to build cells that can perform specific tasks, such as counting mitotic divisions, measuring life span and remembering past events. I will discuss the successful design and construction of a eukaryotic memory device with predictable biological properties as well as a synthetic oscillator based on localization in cancer cells. |
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