Structure modeling of 907 G protein-coupled receptors in The Human genome

Modeling results of TASSER for all 907 G protein-coupled receptors (GPCRs) in human genome. All sequences were collected from the GPCR database http://www.gpcr.org/7tm/ and http://www.expasy.org/cgi-bin/lists?7tmrlist.txt.

Reference: Zhang Y, Devries ME, Skolnick J. Structure Modeling of All Identified G Protein-Coupled Receptors in the Human Genome. PLoS Comput Biol. 2006 Feb 17;2(2):e13 PDF

Note: Commercial users may have access to the set of GPCR models after completing the license agreement and sending it to skolnick@gatech.edu

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Summary of folding results:

• ID --- SWISS-PROT Identifier of the proteins.
• Length --- Number of residues in the sequence.
• Sequence --- Amino acid sequence from http://www.gpcr.org/7tm/ and http://www.expasy.org/cgi-bin/lists?7tmrlist.txt.
• Template --- Template identified by the threading program PROSPECTOR_3.
• Models --- Top five models generated by TASSER.
• C-score --- Confidence score of the predicted models. The higher the C-score is, the more likely it is that a correct model is generated.
• N-helix --- Number of helices > 17 residues in the first (top ranked) model.
• Topology --- Topology of the first model.

• Transmembrane --- Transmembrane helix bundle.
• Globular --- Globular protein conformation.

• Description --- Description of the proteins according to the SWISS-PROT database.

[Table I]
[Table II]
[Table III]